Luteoloside inhibiting the prostate cancer cells growth and promoting the tumor cells autophagy through AKT/mTOR pathway

Prostate cancer (PC) is one of the prevalent tumors in men causing higher mortality. Luteoloside has been discovered for suppressive role into progression some cancers. However, Luteoloside’s regulatory functions regarding PC are not well understood. This study thus designed to investigate impact on progression. In this work, it was demonstrated that cell proliferation gradually inhibited with increasing dose (0, 20, 40, 80 µM). also enhanced apoptosis. It promoted autophagy through microtubule-associated protein light chain (LC) 3II/LC3I levels and decreasing p62 levels. Moreover, reduced phosphorylated-protein kinase B (p-AKT)/AKT phosphorylated-mechanistic target rapamycin (p-mTOR)/mTOR levels, indicating retarded AKT/mTOR pathway. conclusion, cells growth tumor discovery suggested as a potential drug treating PC.